Interleukin 2 (IL2) (Active) Protein

Details for Product No. ABIN4889954, Supplier: Log in to see
Protein Name
  • IL2
  • IL-2
  • il2
  • TCGF
  • lymphokine
  • Il-2
  • POIL2
  • interleukin 2
  • interleukin-15
  • IL2
  • il2
  • LOC100303688
  • Il2
Origin
Rat (Rattus)
89
50
29
7
6
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Source
Escherichia coli (E. coli)
139
26
15
7
3
2
1
1
1
1
1
Protein Type
Recombinant
Biological Activity
Active
Application
ELISA, In vitro Assay (in vitro), In vivo Studies (in vivo), Western Blotting (WB)
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Sequence MAPTSSPAKE TQQHLEQLLL DLQVLLRGID NYKNLKLPMM LTFKFYLPKQ ATELKHLQCL ENELGALQRV LDLTQSKSFH LEDAGNFISN IRVTVVKLKG SENKFECQFD DEPATVVEFL RRWIAICQSI ISTMTQ
Purity ≥ 95%
Sterility 0.2 μm filtered
Endotoxin Level ≤ 1.00 LAL (EUs/ug)
Grade Animal-Free
Biological Activity Comment
  • Bioactivity Assay: CTLL-2 Proliferation
  • Bioactivity Acceptance Criteria ED50 (ng/ml): 2 ng/mL
  • Bioactivity Acceptance Criteria (Units/mg): 5 x 10^5 units/mg
Protein Name
Background Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.  IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

Alternate Names: T cell growth factor, TCGF, Aldesleukin
Molecular Weight Monomer: 15.6 MW Monomer/Total (kDa)
UniProt P17108
Pathways JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Media Components: Luria Broth

Animal Components: This product is produced with no animal-derived raw products. All processing and handling employs animal-free equipment and animal-free protocols.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Sterile 10 mM HCl at 0.1 mg/mL
Buffer Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing : 0.1 % Trifluoroacetic Acid (TFA)
Preservative Without preservative
Handling Advice Centrifuge vial before opening.
Storage 4 °C,-20 °C,-80 °C
Storage Comment 12 months from date of receipt when stored at -20°C to-80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.
Expiry Date 12 months