Interleukin 1 alpha (IL1A) (Active) Protein

Details for Product No. ABIN4889959
Protein Name
  • IL-1A
  • IL1
  • IL1-ALPHA
  • IL1F1
  • Il-1a
  • IL-1 alpha
  • IL-1alpha
  • L1A
  • interleukin 1 alpha
  • IL1A
  • Il1a
Origin
Mouse (Murine)
59
30
17
6
4
3
3
3
3
3
2
2
2
1
1
1
1
Source
Escherichia coli (E. coli)
111
13
2
2
2
1
1
Protein Type
Recombinant
Biological Activity
Active
Application
ELISA, In vitro Assay (in vitro), In vivo Studies (in vivo), Western Blotting (WB)
Options
Sequence MSAPYTYQSD LRYKLMKLVR QKFVMNDSLN QTIYQDVDKH YLSTTWLNDL QQEVKFDMYA YSSGGDDSKY PVTLKISDSQ LFVSAQGEDQ PVLLKELPET PKLITGSETD LIFFWKSINS KNYFTSAAYP ELFIATKEQS RVHLARGLPS MTDFQIS
Purity ≥ 95%
Sterility 0.2 μm filtered
Endotoxin Level ≤ 1.00 LAL (EUs/ug)
Biological Activity Comment
  • Bioactivity Assay: D10.G4.1 proliferation
  • Bioactivity Acceptance Criteria ED50 (ng/ml): 10 pg/mL
  • Bioactivity Acceptance Criteria (Units/mg): 1.0 x 10^8 units/mg
Protein Name
Background Interleukin 1 alpha (IL-1α) is expressed by epithelial cells, activated macrophages, neutrophils, and endothelial cells to regulate immune responses. IL-1α signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1α and the independently regulated IL-1β protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

Alternate Names: None
Molecular Weight Monomer: 18.1 MW Monomer/Total (kDa)
UniProt P01582
Pathways NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Media Components: Luria Broth

Restrictions For Research Use only
Format Lyophilized
Reconstitution Sterile water at 0.1 mg/mL
Buffer Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing : 10 mM sodium phosphate,  pH 7.5
Preservative Without preservative
Handling Advice Centrifuge vial before opening.
Storage 4 °C,-20 °C,-80 °C
Storage Comment 12 months from date of receipt when stored at -20°C to-80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.
Expiry Date 12 months
Supplier Images
 image for Interleukin 1 alpha (IL1A) (Active) protein (ABIN4889959) Interleukin 1 alpha (IL1A) (Active) protein
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