Haptoglobin (HP) Protein

Details for Product No. ABIN491578, Supplier: Log in to see
Protein Name
  • HP
  • wu:fb64e01
  • BP
  • HP2ALPHA2
  • HPA1S
  • HP-1
  • HPR
  • Zonulin
  • haptoglobin
  • haptoglobin-like
  • HP
  • hp
  • Hp
  • LOC479668
  • LOC101102413
Origin
Human
30
7
5
4
4
4
3
2
1
1
1
1
1
1
1
Source
Human
23
13
12
5
2
1
1
1
1
1
1
1
Protein Type
Native
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Characteristics An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes. Hp 1-1 is the most common, and the most effective in binding free hemoglobin. Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. Molecular Weights by phenotype - Hp 1-1: 86,000, Hp 2-1: 200,000, Hp 2-2: 400,000.
Purification Chromatographically purified
Purity > 95 % by SDS-PAGE
Gene ID 3240
UniProt P00738
Pathways Transition Metal Ion Homeostasis
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add deionized water to original volume, aliquot and freeze unused portion.
Buffer Salt free
Storage -80 °C
Supplier Images
SDS-PAGE (SDS) image for Haptoglobin (HP) protein (ABIN491578) Haptoglobin (HP) protein
Product cited in: Almeida, Souza, Leonardo, Costa, Werneck, Covas, Costa, Conran: "Acute hemolytic vascular inflammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea." in: Blood, Vol. 126, Issue 6, pp. 711-20, 2015 (PubMed).

Zapotoczna, Heilbronner, Speziale, Foster: "Iron-regulated surface determinant (Isd) proteins of Staphylococcus lugdunensis." in: Journal of bacteriology, Vol. 194, Issue 23, pp. 6453-67, 2012 (PubMed).

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