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CD3 epsilon Protein (CD3E) (AA 23-108) (Fc Tag)

CD3E Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func
Catalog No. ABIN4949162
  • Target See all CD3 epsilon (CD3E) Proteins
    CD3 epsilon (CD3E)
    Protein Type
    Recombinant
    Protein Characteristics
    AA 23-108
    Origin
    • 25
    • 9
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Source
    • 22
    • 8
    • 5
    • 5
    • 2
    • 2
    HEK-293 Cells
    Purification tag / Conjugate
    This CD3 epsilon protein is labelled with Fc Tag.
    Application
    Functional Studies (Func)
    Sequence
    AA 23-108
    Characteristics
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 36 kDa. The protein migrates as 45 kDa under reducing (R) condition (SDS-PAGE).
    Purity
    >95 % as determined by SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CD3E Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
  • Target
    CD3 epsilon (CD3E)
    Alternative Name
    CD3 epsilon (CD3E Products)
    Synonyms
    cd3e Protein, CD3E Protein, t3e Protein, tcre Protein, AI504783 Protein, CD3 Protein, CD3epsilon Protein, T3e Protein, T3E Protein, TCRE Protein, CD3e molecule Protein, CD3 antigen, epsilon polypeptide Protein, cd3e Protein, CD3E Protein, Cd3e Protein
    Background
    CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
    Molecular Weight
    36 kDa
    UniProt
    P22646
    Pathways
    TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
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