Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

PDCD1LG2 Protein (AA 20-219) (Fc Tag)

PDCD1LG2 Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func
Catalog No. ABIN4949187
  • Target See all PDCD1LG2 Proteins
    PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 20-219
    Origin
    • 30
    • 12
    • 2
    • 2
    Mouse
    Source
    • 26
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This PDCD1LG2 protein is labelled with Fc Tag.
    Application
    Functional Studies (Func)
    Sequence
    AA 20-219
    Characteristics
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.2 kDa. As a result of glycosylation, the protein migrates as 60-70 kDa under reducing (R) condition, and 120-140 kDa under non-reducing (NR) condition (SDS-PAGE).
    Purity
    >95 % as determined by SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product PDCD1LG2 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
  • Tocheva, Peled, Strazza, Adam, Lerrer, Nayak, Azoulay-Alfaguter, Foster, Philips, Neel, Ueberheide, Mor: "Quantitative phosphoproteomic analysis reveals involvement of PD-1 in multiple T cell functions." in: The Journal of biological chemistry, Vol. 295, Issue 52, pp. 18036-18050, (2020) (PubMed).

  • Target
    PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
    Alternative Name
    PD-L2 (PDCD1LG2 Products)
    Synonyms
    PDL2 Protein, B7DC Protein, Btdc Protein, CD273 Protein, PD-L2 Protein, PDCD1L2 Protein, bA574F11.2 Protein, B7-DC Protein, F730015O22Rik Protein, programmed cell death 1 ligand 2 Protein, PDCD1LG2 Protein, Pdcd1lg2 Protein
    Background
    Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
    Molecular Weight
    49.2 kDa
    NCBI Accession
    NP_067371
You are here:
Support