Transferrin Receptor 2 Protein (TFR2) (AA 103-798) (Fc Tag)
(1 reference)-
- Target See all Transferrin Receptor 2 (TFR2) Proteins
- Transferrin Receptor 2 (TFR2)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 103-798
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Transferrin Receptor 2 protein is labelled with Fc Tag.
- Application
- Functional Studies (Func)
- Sequence
- AA 103-798
- Characteristics
- This protein carries a mouse IgG1 Fc tag at the N-terminus, and has a calculated MW of 103.2 kDa. The predicted N-terminus is Ile. The reducing (R) protein migrates as 116 kDa in SDS-PAGE due to glycosylation.
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 0.1 EU per μg by the LAL method.
- Top Product
- Discover our top product TFR2 Protein
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Transferrin Receptor 2 (TFR2) (AA 105-801) protein (His tag)
Crystallography grade TFR2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Transferrin Receptor 2 (TFR2) (AA 103-798) protein (His tag)Crystallography grade TFR2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Transferrin Receptor 2 (TFR2) (AA 1-801) protein (Strep Tag)Crystallography grade TFR2 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Transferrin Receptor 2 (TFR2) (AA 1-798) protein (Strep Tag)Crystallography grade TFR2 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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: "Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 35, Issue 2, pp. e21172, (2021) (PubMed).
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: "Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 35, Issue 2, pp. e21172, (2021) (PubMed).
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- Target
- Transferrin Receptor 2 (TFR2)
- Alternative Name
- Transferrin R2 (TFR2 Products)
- Synonyms
- TFR2 Protein, Trfr2 Protein, HFE3 Protein, TFRC2 Protein, zgc:123043 Protein, transferrin receptor 2 Protein, TFR2 Protein, Tfr2 Protein, tfr2 Protein
- Background
- Transferrin receptor protein 2 (TFR2) is a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. The mutations in TFR2 gene have been associated with hereditary hemochromatosis type III. Furthermore, TFR2 is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.
- Molecular Weight
- 101.1 kDa
- NCBI Accession
- NP_056614
- UniProt
- Q9JKX3
- Pathways
- Transition Metal Ion Homeostasis
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