Transferrin Receptor 2 Protein (TFR2) (AA 103-798) (Fc Tag)
(1 reference)Quick Overview for Transferrin Receptor 2 Protein (TFR2) (AA 103-798) (Fc Tag) (ABIN4949192)
Target
See all Transferrin Receptor 2 (TFR2) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 103-798
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Purification tag / Conjugate
- This Transferrin Receptor 2 protein is labelled with Fc Tag.
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Sequence
- AA 103-798
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Characteristics
- This protein carries a mouse IgG1 Fc tag at the N-terminus, and has a calculated MW of 103.2 kDa. The predicted N-terminus is Ile. The reducing (R) protein migrates as 116 kDa in SDS-PAGE due to glycosylation.
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Endotoxin Level
- Less than 0.1 EU per μg by the LAL method.
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Transferrin Receptor 2 (TFR2) (AA 1-798) protein (His tag)
custom-made TFR2 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Transferrin Receptor 2 (TFR2) (AA 1-801) protein (His tag)custom-made TFR2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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: "Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 35, Issue 2, pp. e21172, (2021) (PubMed).
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: "Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 35, Issue 2, pp. e21172, (2021) (PubMed).
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- Transferrin Receptor 2 (TFR2)
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Alternative Name
- Transferrin R2
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Background
- Transferrin receptor protein 2 (TFR2) is a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. The mutations in TFR2 gene have been associated with hereditary hemochromatosis type III. Furthermore, TFR2 is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.
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Molecular Weight
- 101.1 kDa
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NCBI Accession
- NP_056614
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UniProt
- Q9JKX3
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Pathways
- Transition Metal Ion Homeostasis
Target
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