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MOB1A Protein (AA 2-216) (His-SUMO Tag)

MOBKL1B Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Catalog No. ABIN4975971
  • Target See all MOB1A (MOBKL1B) Proteins
    MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 2-216
    Origin
    • 6
    • 1
    • 1
    Human
    Source
    • 5
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This MOB1A protein is labelled with His-SUMO Tag.
    Application
    SDS-PAGE (SDS)
    Sequence
    SFLFSSRSSK TFKPKKNIPE GSHQYELLKH AEATLGSGNL RQAVMLPEGE DLNEWIAVNT VDFFNQINML YGTITEFCTE ASCPVMSAGP RYEYHWADGT NIKKPIKCSA PKYIDYLMTW VQDQLDDETL FPSKIGVPFP KNFMSVAKTI LKRLFRVYAH IYHQHFDSVM QLQEEAHLNT SFKHFIFFVQ EFNLIDRREL APLQELIEKL GSKDR
    Purification
    SDS-PAGE
    Purity
    > 90 %
    Top Product
    Discover our top product MOBKL1B Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Storage
    -80 °C,4 °C,-20 °C
    Storage Comment
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Target
    MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))
    Alternative Name
    MOB1A (MOBKL1B Products)
    Synonyms
    mob1 Protein, mob4b Protein, MOB1A Protein, MOBK1B Protein, MOB1 Protein, mats1 Protein, mobk1b Protein, mobkl1b Protein, MOBKL1B Protein, wu:fv69d04 Protein, zgc:56189 Protein, C2orf6 Protein, MATS1 Protein, Mob4B Protein, 4022402H07Rik Protein, MOB4B Protein, Mobk1b Protein, Mobkl1b Protein, MOB kinase activator 1A L homeolog Protein, MOB kinase activator 1A Protein, MOB kinase activator 1A pseudogene Protein, mob1a.L Protein, MOB1A Protein, mob1a Protein, LOC712156 Protein, Mob1a Protein
    Background
    Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.
    Molecular Weight
    40.9 kDa
    UniProt
    Q9H8S9
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