HSD17B10 Protein (AA 2-261) (His-SUMO Tag)

Catalog No. ABIN4975977

Product Details

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Protein Type: Recombinant

Protein Characteristics: AA 2-261

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This HSD17B10 protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: AAACRSVKGL VAVITGGASG LGLATAERLV GQGASAVLLD LPNSGGEAQA KKLGNNCVFA PADVTSEKDV QTALALAKGK FGRVDVAVNC AGIAVASKTY NLKKGQTHTL EDFQRVLDVN LMGTFNVIRL VAGEMGQNEP DQGGQRGVII NTASVAAFEG QVGQAAYSAS KGGIVGMTLP IARDLAPIGI RVMTIAPGLF GTPLLTSLPE KVCNFLASQV PFPSRLGDPA EYAHLVQAII ENPFLNGEVI RLDGAIRMQP

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Alternative Name: HCD2 (HSD17B10 Products)

Synonyms: hadh2 Protein, im:6899159 Protein, wu:fj61f03 Protein, zgc:101605 Protein, abad Protein, camr Protein, erab Protein, hcd2 Protein, hsd10 Protein, mhbd Protein, mrpp2 Protein, mrx17 Protein, mrx31 Protein, mrxs10 Protein, schad Protein, sdr5c1 Protein, HADH2 Protein, HSD17B10 Protein, 17b-HSD10 Protein, ABAD Protein, CAMR Protein, DUPXp11.22 Protein, ERAB Protein, HCD2 Protein, MHBD Protein, MRPP2 Protein, MRX17 Protein, MRX31 Protein, MRXS10 Protein, SCHAD Protein, SDR5C1 Protein, 17bHSD10 Protein, Ads9 Protein, Hadh2 Protein, hydroxysteroid (17-beta) dehydrogenase 10 Protein, hydroxysteroid 17-beta dehydrogenase 10 Protein, hydroxysteroid (17-beta) dehydrogenase 10 L homeolog Protein, HSD17B10 Protein, hsd17b10 Protein, hsd17b10.L Protein, Hsd17b10 Protein

Background: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

Molecular Weight: 42.8 kDa

UniProt: Q99714