IL1F10 Protein (AA 20-152) (His tag)
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- Target See all IL1F10 Proteins
- IL1F10 (Interleukin 1 Family, Member 10 (Theta) (IL1F10))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 20-152
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This IL1F10 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Cross-Reactivity
- Human
- Characteristics
- Human IL-38 (aa Leu20-Trp152) is fused at the C-terminus to a His-tag.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product IL1F10 Protein
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Interleukin 1 Family, Member 10 (Theta) (IL1F10) (AA 1-152) protein (His tag)
IL1F10 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 1 Family, Member 10 (Theta) (IL1F10) (AA 1-152) protein (Strep Tag)Crystallography grade IL1F10 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Interleukin 1 Family, Member 10 (Theta) (IL1F10) (AA 1-152) protein (Strep Tag)Crystallography grade IL1F10 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Solid
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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- Target
- IL1F10 (Interleukin 1 Family, Member 10 (Theta) (IL1F10))
- Alternative Name
- IL-38 (IL1F10 Products)
- Synonyms
- FIL1-theta Protein, IL-1HY2 Protein, IL-38 Protein, IL1-theta Protein, IL1HY2 Protein, interleukin 1 family, member 10 Protein, interleukin 1 family member 10 Protein, Il1f10 Protein, IL1F10 Protein
- Background
- IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1, TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.
- Molecular Weight
- ~16kDa
- UniProt
- Q8WWZ1
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