LRRC32 Protein (partial) (Fc Tag)
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- Target See all LRRC32 Proteins
- LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- partial
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This LRRC32 protein is labelled with Fc Tag.
- Application
- Western Blotting (WB), ELISA
- Sequence
- His 20 - Asn 627
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Endotoxin level is less than 1.0 EU per ug by the LAL method.
- Biological Activity Comment
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Measured by its binding ability in a functional ELISA. Immobilized Latent TGFB1, N-His at 5 μg/mL (100 uL/well) can bind Human LRRC32, Fc Tag with a linear range of 0.039-2.5 μg/mL (QC tested).
- Top Product
- Discover our top product LRRC32 Protein
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Leucine Rich Repeat Containing 32 (LRRC32) protein (Fc Tag)
LRRC32 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Leucine Rich Repeat Containing 32 (LRRC32) (AA 20-627) protein (His tag)Crystallography grade LRRC32 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Leucine Rich Repeat Containing 32 (LRRC32) (AA 20-662) protein (rho-1D4 tag)Crystallography grade LRRC32 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Leucine Rich Repeat Containing 32 (LRRC32) (AA 20-627) protein (Fc Tag)LRRC32 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Leucine Rich Repeat Containing 32 (LRRC32) proteinLRRC32 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, ELISA, IP
Leucine Rich Repeat Containing 32 (LRRC32) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)LRRC32 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- This recombinant protein can be used for E, WB.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM Glycine, pH 7.5
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
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- Target
- LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))
- Alternative Name
- LRRC32 (LRRC32 Products)
- Synonyms
- D11S833E Protein, GARP Protein, AI426318 Protein, D11S833Eh Protein, D7H11S833E Protein, EG434215 Protein, Garp Protein, leucine rich repeat containing 32 Protein, LRRC32 Protein, Lrrc32 Protein
- Background
- Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naive T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naive T cell proliferation.
- Molecular Weight
- 92.6 kDa
- Gene ID
- 2615
- Pathways
- Activated T Cell Proliferation
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