LRRC32 Protein (AA 20-627) (Fc Tag)

Catalog No. ABIN5674638

Product Details

Target: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Protein Type: Recombinant

Protein Characteristics: AA 20-627

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This LRRC32 protein is labelled with Fc Tag.

Sequence: AA 20-627

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.6 kDa. The protein migrates as 35 kDa and 100-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: >95 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Target Details

Target: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Alternative Name: LRRC32 (LRRC32 Products)

Synonyms: D11S833E Protein, GARP Protein, AI426318 Protein, D11S833Eh Protein, D7H11S833E Protein, EG434215 Protein, Garp Protein, leucine rich repeat containing 32 Protein, LRRC32 Protein, Lrrc32 Protein

Background: Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naive T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naive T cell proliferation.

Molecular Weight: 92.4 kDa

NCBI Accession: NP_005503

Pathways: Activated T Cell Proliferation