KCNJ1 Protein (AA 178-391, Cytoplasmic Domain, Cytosolic) (His tag)

Catalog No. ABIN5709793

Product Details

Target: KCNJ1 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))

Protein Type: Recombinant

Protein Characteristics: Cytosolic, AA 178-391, Cytoplasmic Domain

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This KCNJ1 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: ILAKISRPKK RAKTITFSKN AVISKRGGKL CLLIRVANLR KSLLIGSHIY GKLLKTTVTP EGETIILDQI NINFVVDAGN ENLFFISPLT IYHVIDHNSP FFHMAAETLL QQDFELVVFL DGTVESTSAT CQVRTSYVPE EVLWGYRFAP IVSKTKEGKY RVDFHNFSKT VEVETPHCAM CLYNEKDVRA RMKRGYDNPN FILSEVNETD DTKM

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: KCNJ1 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))

Alternative Name: KCNJ1 (KCNJ1 Products)

Synonyms: KIR1.1 Protein, ROMK Protein, ROMK1 Protein, kir1.1 Protein, romk1 Protein, Kcnj Protein, Kir1.1 Protein, Romk2 Protein, kcnj1 Protein, wu:fl37c05 Protein, zgc:63534 Protein, potassium voltage-gated channel subfamily J member 1 Protein, potassium voltage-gated channel subfamily J member 1 L homeolog Protein, potassium inwardly-rectifying channel, subfamily J, member 1 Protein, potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1 Protein, KCNJ1 Protein, kcnj1.L Protein, kcnj1 Protein, Kcnj1 Protein, kcnj1a.1 Protein

Background: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.

Molecular Weight: 28.4 kDa

UniProt: P48048