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Sortilin 1 Protein (SORT1) (AA 610-754) (His-SUMO Tag)

SORT1 Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Catalog No. ABIN5710402
  • Target See all Sortilin 1 (SORT1) Proteins
    Sortilin 1 (SORT1)
    Protein Type
    Recombinant
    Protein Characteristics
    AA 610-754
    Origin
    • 7
    • 3
    • 2
    Rat
    Source
    • 4
    • 3
    • 3
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This Sortilin 1 protein is labelled with His-SUMO Tag.
    Application
    SDS-PAGE (SDS)
    Sequence
    CEENDYTTWL AHSTDPGDYK DGCILGYKEQ FLRLRKSSVC QNGRDYVVAK QPSICPCSLE DFLCDFGYFR PENASECVEQ PELKGHELEF CLYGKEEHLT TNGYRKIPGD RCQGGMNPAR EVKDLKKKCT SNFLNPKKQN SKSSS
    Purification
    SDS-PAGE
    Purity
    > 90 %
    Top Product
    Discover our top product SORT1 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Storage
    -80 °C,4 °C,-20 °C
    Storage Comment
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Target
    Sortilin 1 (SORT1)
    Alternative Name
    SORT (SORT1 Products)
    Synonyms
    SORT1 Protein, 19.m02079 Protein, gp95 Protein, ldlcq6 Protein, sortilin Protein, Gp95 Protein, LDLCQ6 Protein, NT3 Protein, 2900053A11Rik Protein, AI852375 Protein, Ntr3 Protein, Ntsr3 Protein, Nt3 Protein, Nts3 Protein, sort1 Protein, zgc:85953 Protein, sortilin 1 Protein, sortilin Protein, sortilin 1 S homeolog Protein, sortilin 1a Protein, SORT1 Protein, TP01_0016 Protein, BBOV_I002730 Protein, sort1.S Protein, Sort1 Protein, sort1a Protein
    Background
    Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
    Molecular Weight
    32.5 kDa
    UniProt
    O54861
    Pathways
    Neurotrophin Signaling Pathway
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