SYT1 Protein (AA 99-416, Cytoplasmic Domain, Cytosolic) (His tag)

Catalog No. ABIN5710450

Product Details

Target: SYT1 (Synaptotagmin I (SYT1))

Protein Type: Recombinant

Protein Characteristics: Cytosolic, AA 99-416, Cytoplasmic Domain

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SYT1 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: KNAINMKDVK DLGKTMKDQA LKDDDAETGL TDGEEKEEPK EEEKLGKLQY SLDYDFQNNQ LLVGIIQAAE LPALDMGGTS DPYVKVFLLP DKKKKFETKV HRKTLNPVFN EQFTFKVPYS ELGGKTLVMA VYDFDRFSKH DIIGEFKVPM NTVDFGHVTE EWRDLQSAEK EEQEKLGDIC FSLRYVPTAG KLTVVILEAK NLKKMDVGGL SDPYVKIHLM QNGKRLKKKK TTIKKNTLNP YYNESFSFEV PFEQIQKVQV VVTVLDYDKI GKNDAIGKVF VGYNSTGAEL RHWSDMLANP RRPIAQWHTL QVEEEVDA

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: SYT1 (Synaptotagmin I (SYT1))

Alternative Name: SYT1 (SYT1 Products)

Synonyms: P65 Protein, SVP65 Protein, SYT Protein, CG3139 Protein, D. Syt I Protein, DSYT Protein, DSYT2 Protein, DSypt Protein, DSyt Protein, Dmel\\CG3139 Protein, Droso1 Protein, Dsyt2 Protein, SYT I Protein, SYT1 Protein, Syt Protein, Syt 1 Protein, Syt I Protein, Syt-1 Protein, SytI Protein, dSYT Protein, dsyt1 Protein, dsytI Protein, l(2)23AB1 Protein, l(2)23Ba Protein, l(2)k05909 Protein, syt Protein, syt 1 Protein, syt I Protein, syt-1 Protein, syt1 Protein, sytI Protein, AW124717 Protein, G630098F17Rik Protein, Syti Protein, GB20036 Protein, DKFZP459P193 Protein, svp65 Protein, p65 Protein, wu:fj41c01 Protein, wu:fk56d05 Protein, zgc:92899 Protein, synaptotagmin 1 Protein, Synaptotagmin 1 Protein, synaptotagmin I Protein, synaptotagmin-1 Protein, synaptotagmin, p65 Protein, synaptotagmin Ia Protein, synaptotagmin 1 L homeolog Protein, SYT1 Protein, Syt1 Protein, Tsp_06980 Protein, Tsp_08220 Protein, syt1 Protein, LOC100533340 Protein, syt1a Protein, syt1.L Protein

Background: May have a regulatory role in the mbrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca2+-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca2+-independent manner, these are neurexins, syntaxin and AP2.

Molecular Weight: 40.4 kDa

UniProt: P21579

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport