SKP2 Protein (AA 1-424, full length) (His-SUMO Tag)
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- Target See all SKP2 Proteins
- SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
- Protein Type
- Recombinant
- Protein Characteristics
- full length, AA 1-424
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This SKP2 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MHRKHLQEIP DLSSNVATSF TWGWDSSKTS ELLSGMGVSA LEKEEPDSEN IPQELLSNLG HPESPPRKRL KSKGSDKDFV IVRRPKLNRE NFPGVSWDSL PDELLLGIFS CLCLPELLKV SGVCKRWYRL ASDESLWQTL DLTGKNLHPD VTGRLLSQGV IAFRCPRSFM DQPLAEHFSP FRVQHMDLSN SVIEVSTLHG ILSQCSKLQN LSLEGLRLSD PIVNTLAKNS NLVRLNLSGC SGFSEFALQT LLSSCSRLDE LNLSWCFDFT EKHVQVAVAH VSETITQLNL SGYRKNLQKS DLSTLVRRCP NLVHLDLSDS VMLKNDCFQE FFQLNYLQHL SLSRCYDIIP ETLLELGEIP TLKTLQVFGI VPDGTLQLLK EALPHLQINC SHFTTIARPT IGNKKNQEIW GIKCRLTLQK PSCL
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product SKP2 Protein
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S-Phase Kinase-Associated Protein 2 (SKP2) (AA 1-424) protein (GST tag)
SKP2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
S-Phase Kinase-Associated Protein 2 (SKP2) (AA 176-285) protein (GST tag)SKP2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
S-Phase Kinase-Associated Protein 2 (SKP2) (AA 1-424) protein (Strep Tag)Crystallography grade SKP2 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
S-Phase Kinase-Associated Protein 2 (SKP2) (AA 1-424) protein (Strep Tag)Crystallography grade SKP2 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
S-Phase Kinase-Associated Protein 2 (SKP2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)SKP2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
- Alternative Name
- SKP2 (SKP2 Products)
- Synonyms
- FBXL1 Protein, FBL1 Protein, FLB1 Protein, p45 Protein, RGD1562456 Protein, S-phase kinase-associated protein 2 (p45) Protein, S-phase kinase associated protein 2 Protein, Skp2 Protein, SKP2 Protein
- Background
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration
- Molecular Weight
- 63.73 kDa
- UniProt
- Q13309
- Pathways
- Mitotic G1-G1/S Phases
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