SART3 Protein (AA 600-900, partial) (His-SUMO Tag)
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- Target See all SART3 Proteins
- SART3 (Squamous Cell Carcinoma Antigen Recognized By T Cells 3 (SART3))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 600-900, partial
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This SART3 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- QRKRARAEKK ALKKKKKIRG PEKRGADEDD EKEWGDDEEE QPSKRRRVEN SIPAAGETQN VEVAAGPAGK CAAVDVEPPS KQKEKAASLK RDMPKVLHDS SKDSITVFVS NLPYSMQEPD TKLRPLFEAC GEVVQIRPIF SNRGDFRGYC YVEFKEEKSA LQALEMDRKS VEGRPMFVSP CVDKSKNPDF KVFRYSTSLE KHKLFISGLP FSCTKEELEE ICKAHGTVKD LRLVTNRAGK PKGLAYVEYE NESQASQAVM KMDGMTIKEN IIKVAISNPP QRKVPEKPET RKAPGGPMLL P
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product SART3 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- SART3 (Squamous Cell Carcinoma Antigen Recognized By T Cells 3 (SART3))
- Alternative Name
- SART3 (SART3 Products)
- Synonyms
- SART3 Protein, DKFZp469J2418 Protein, si:ch211-191d15.4 Protein, wu:fc51h03 Protein, DSAP1 Protein, P100 Protein, RP11-13G14 Protein, TIP110 Protein, p110 Protein, p110(nrb) Protein, AU045857 Protein, mKIAA0156 Protein, squamous cell carcinoma antigen recognized by T-cells 3 Protein, squamous cell carcinoma antigen recognized by T-cells 3 L homeolog Protein, squamous cell carcinoma antigen recognized by T cells 3 Protein, SART3 Protein, sart3 Protein, sart3.L Protein, Sart3 Protein
- Background
- U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassbly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation . Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assbly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites . May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassbly . May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair . May play a role in hatopoiesis probably through transcription regulation of specific genes including MYC .
- Molecular Weight
- 49.82 kDa
- UniProt
- Q15020
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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