DCUN1D1 Protein (AA 1-259, full length) (His-SUMO Tag)
-
- Target See all DCUN1D1 Proteins
- DCUN1D1 (Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1))
- Protein Type
- Recombinant
- Protein Characteristics
- full length, AA 1-259
-
Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This DCUN1D1 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MNKLKSSQKD KVRQFMIFTQ SSEKTAVSCL SQNDWKLDVA TDNFFQNPEL YIRESVKGSL DRKKLEQLYN RYKDPQDENK IGIDGIQQFC DDLALDPASI SVLIIAWKFR AATQCEFSKQ EFMDGMTELG CDSIEKLKAQ IPKMEQELKE PGRFKDFYQF TFNFAKNPGQ KGLDLEMAIA YWNLVLNGRF KFLDLWNKFL LEHHKRSIPK DTWNLLLDFS TMIADDMSNY DEEGAWPVLI DDFVEFARPQ IAGTKSTTV
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product DCUN1D1 Protein
-
Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1) (AA 1-259) protein (His tag)
DCUN1D1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1) (AA 1-259) protein (GST tag)DCUN1D1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1) (AA 1-89) protein (GST tag)DCUN1D1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1) (AA 1-259) protein (Strep Tag)Crystallography grade DCUN1D1 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1) protein (Myc-DYKDDDDK Tag)DCUN1D1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
- Target
- DCUN1D1 (Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1))
- Alternative Name
- DCNL1 (DCUN1D1 Products)
- Synonyms
- fd19a01 Protein, zgc:66414 Protein, wu:fd19a01 Protein, dcun1l1 Protein, rp42 Protein, sccro Protein, scro Protein, tes3 Protein, DCNL1 Protein, DCUN1L1 Protein, RP42 Protein, SCCRO Protein, SCRO Protein, Tes3 Protein, Rp42 Protein, pTes3 Protein, DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) Protein, DCN1-like protein 1 Protein, DCN1, defective in cullin neddylation 1, domain containing 1 L homeolog Protein, defective in cullin neddylation 1 domain containing 1 Protein, dcun1d1 Protein, dcnl1 Protein, dcun1d1.L Protein, DCUN1D1 Protein, Dcun1d1 Protein
- Background
- Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates . Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assbly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression .1 Publication
- Molecular Weight
- 46.1 kDa
- UniProt
- Q96GG9
-
