TEAD3 Protein (AA 112-435, partial) (His-SUMO Tag)

Catalog No. ABIN5711743

Product Details

Target: TEAD3 (TEA Domain Family Member 3 (TEAD3))

Protein Type: Recombinant

Protein Characteristics: AA 112-435, partial

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TEAD3 protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: MNLDQVSKDK ALQSMASMSS AQIVSASVLQ NKFSPPSPLP QAVFSTSSRF WSSPPLLGQQ PGPSQDIKPF AQPAYPIQPP LPPTLSSYEP LAPLPSAAAS VPVWQDRTIA SSRLRLLEYS AFMEVQRDPD TYSKHLFVHI GQTNPAFSDP PLEAVDVRQI YDKFPEKKGG LKELYEKGPP NAFFLVKFWA DLNSTIQEGP GAFYGVSSQY SSADSMTISV STKVCSFGKQ VVEKVETEYA RLENGRFVYR IHRSPMCEYM INFIHKLKHL PEKYMMNSVL ENFTILQVVT SRDSQETLLV IAFVFEVSTS EHGAQHHVYK LVKD

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: TEAD3 (TEA Domain Family Member 3 (TEAD3))

Alternative Name: TEAD3 (TEAD3 Products)

Synonyms: DTEF-1 Protein, TEF-5 Protein, ETFR-1 Protein, TEAD-3 Protein, TEAD5 Protein, TEF5 Protein, Tcf13r2 Protein, cb882 Protein, tead3 Protein, TEA domain transcription factor 3 Protein, TEA domain family member 3 Protein, TEA domain family member 3 a Protein, tubby like protein 1 Protein, TEAD3 Protein, Tead3 Protein, tead3a Protein, TULP1 Protein

Background: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (T) induction. Binds to multiple functional elents of the human chorionic somatomammotropin-B gene enhancer.

Molecular Weight: 52.3 kDa

UniProt: Q99594

Pathways: Regulation of Lipid Metabolism by PPARalpha