CPEB1 Protein (AA 1-486, full length) (His-SUMO Tag)

Catalog No. ABIN5711755

Product Details

Target: CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))

Protein Type: Recombinant

Protein Characteristics: AA 1-486, full length

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CPEB1 protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: MLFPTSAQES SRGLPDANDL CLGLQSLSLT GWDRPWSTQD SDSSAQSSTH SVLSMLHNPL GNVLGKPPLS FLPLDPLGSD LVDKFPAPSV RGSRLDTRPI LDSRSSSPSD SDTSGFSSGS DHLSDLISSL RISPPLPFLS LSGGGPRDPL KMGVGSRMDQ EQAALAAVTP SPTSASKRWP GASVWPSWDL LEAPKDPFSI EREARLHRQA AAVNEATCTW SGQLPPRNYK NPIYSCKVFL GGVPWDITEA GLVNTFRVFG SLSVEWPGKD GKHPRCPPKG YVYLVFELEK SVRSLLQACS HDPLSPDGLS EYYFKMSSRR MRCKEVQVIP WVLADSNFVR SPSQRLDPSR TVFVGALHGM LNAEALAAIL NDLFGGVVYA GIDTDKHKYP IGSGRVTFNN QRSYLKAVSA AFVEIKTTKF TKKVQIDPYL EDSLCHICSS QPGPFFCRDQ VCFKYFCRSC WHWRHSMEGL RHHSPLMRNQ KNRDSS

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))

Alternative Name: CPEB1 (CPEB1 Products)

Synonyms: CEBP Protein, CPE-BP1 Protein, CPEB Protein, AU024112 Protein, Cpeb Protein, mCPEB Protein, CPEB1 Protein, cpeb1 Protein, ZOR-1 Protein, cepb1b Protein, fd15c06 Protein, wu:fd15c06 Protein, zorba Protein, cytoplasmic polyadenylation element binding protein 1 Protein, hypothetical protein Protein, cytoplasmic polyadenylation element binding protein 1 L homeolog Protein, cytoplasmic polyadenylation element binding protein 1b Protein, cytoplasmic polyadenylation element binding protein 1 S homeolog Protein, CPEB1 Protein, Cpeb1 Protein, cpeb1 Protein, LOAG_17395 Protein, cpeb1.L Protein, cpeb1b Protein, cpeb1.S Protein

Background: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation elent (CPE), an uridine-rich sequence elent (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA, a repression that is relieved by phosphorylation or degradation . Involved in the transport of CPE-containing mRNA to dendrites, those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses . Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation . Induces the assbly of stress granules in the absence of stress.

Molecular Weight: 69.6 kDa

UniProt: Q9BZB8

Pathways: Synaptic Membrane