DKK2 Protein (AA 34-259) (His-SUMO Tag)
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- Target See all DKK2 Proteins
- DKK2 (Dickkopf 2 Homolog (DKK2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 34-259
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This DKK2 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- KLNSIKSSLG GETPGQAANR SAGMYQGLAF GGSKKGKNLG QAYPCSSDKE CEVGRYCHSP HQGSSACMVC RRKKKRCHRD GMCCPSTRCN NGICIPVTES ILTPHIPALD GTQHRDRNHG HYSNHDLGWQ NLGRPHTKMS HIKGHEGDPC LRSSDCIEGF CCARHFWTKI CKPVLHQGEV CTKQRKKGSH GLEIFQRCDC AKGLSCKVWK DATYSSKARL HVCQKI
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product DKK2 Protein
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Dickkopf 2 Homolog (DKK2) (AA 34-100) protein (His-IF2DI Tag)
DKK2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Dickkopf 2 Homolog (DKK2) (AA 34-259) protein (His tag)DKK2 Origin: Human Host: Escherichia coli (E. coli) Recombinant SDS
Dickkopf 2 Homolog (DKK2) (AA 34-259) protein (His tag)Crystallography grade DKK2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Dickkopf 2 Homolog (DKK2) (AA 34-259) protein (His tag)Crystallography grade DKK2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- DKK2 (Dickkopf 2 Homolog (DKK2))
- Alternative Name
- DKK2 (DKK2 Products)
- Synonyms
- DKK-2 Protein, Dkk4 Protein, zgc:171574 Protein, dickkopf WNT signaling pathway inhibitor 2 Protein, DKK2 Protein, Dkk2 Protein, dkk2 Protein
- Background
- Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmbrane protein KREN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease .
- Molecular Weight
- 41 kDa
- UniProt
- Q9UBU2
- Pathways
- WNT Signaling
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