TCP1 alpha/CCTA Protein (AA 1-680, full length) (His tag)

Catalog No. ABIN5712790

Product Details

Target: TCP1 alpha/CCTA (TCP1) (T-Complex 1 (TCP1))

Protein Type: Recombinant

Protein Characteristics: full length, AA 1-680

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TCP1 alpha/CCTA protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTNEFL SPEVFQHIWD FLEQPICSVQ PIDLNFVDEP SEDGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNSM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSIQSPSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTIPDGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG ILDHRQLHEF SSPSHLLRTP SSASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND FNFDMDARRN KQQRIKEEGE

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: TCP1 alpha/CCTA (TCP1) (T-Complex 1 (TCP1))

Alternative Name: P63 (TCP1 Products)

Synonyms: CCT-alpha Protein, CCT1 Protein, CCTa Protein, D6S230E Protein, TCP-1-alpha Protein, AI528772 Protein, CCT Protein, Cct1 Protein, Ccta Protein, TRic Protein, Tcp-1 Protein, Tp63 Protein, c-cpn Protein, p63 Protein, TRiC Protein, CCTalpha Protein, BEST:GH05123 Protein, CG5374 Protein, Dmel\\CG5374 Protein, T-cpl Protein, TCP-1alpha Protein, TCPA_DROME Protein, Tcp1 Protein, Tcp1-alpha Protein, gh05123 Protein, cct-alpha Protein, ccta Protein, tcp1 Protein, tcp1-a Protein, tcp1a Protein, tcp1alpha Protein, CHUNP6875 Protein, fa13h08 Protein, wu:fa13h08 Protein, wu:fc95g06 Protein, t-complex 1 Protein, T-complex protein 1 subunit alpha Protein, t-complex protein 1 Protein, Tcp1-like Protein, t-complex 1 S homeolog Protein, TCP1 Protein, cct-1 Protein, Tcp1 Protein, T-cp1 Protein, tcp1.S Protein, tcp1 Protein

Background: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial st cell compartments and regulate the initiation of epithelial stratification from the undifferentiated bryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter

Molecular Weight: 80.8 kDa

UniProt: Q9H3D4