FUS Protein (AA 137-574) (His tag)
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- Target See all FUS Proteins
- FUS (Fused in Sarcoma (FUS))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 137-574
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Origin
- Human respiratory syncytial virus B
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Source
- Yeast
- Purification tag / Conjugate
- This FUS protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- FLGFLLGVGS AIASGIAVSK VLHLEGEVNK IKNALLSTNK AVVSLSNGVS VLTSKVLDLK NYINNQLLPI VNQQSCRISN IETVIEFQQK NSRLLEINRE FSVNAGVTTP LSTYMLTNSE LLSLINDMPI TNDQKKLMSS NVQIVRQQSY SIMSIIKEEV LAYVVQLPIY GVIDTPCWKL HTSPLCTTNI KEGSNICLTR TDRGWYCDNA GSVSFFPQAD TCKVQSNRVF CDTMNSLTLP SEVSLCNTDI FNSKYDCKIM TSKTDISSSV ITSLGAIVSC YGKTKCTASN KNRGIIKTFS NGCDYVSNKG VDTVSVGNTL YYVNKLEGKN LYVKGEPIIN YYDPLVFPSD EFDASISQVN EKINQSLAFI RRSDELLHNV NTGKSTTNIM ITTIIIVIIV VLLSLIAIGL LLYCKAKNTP VTLSKDQLSG INNIAFSK
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product FUS Protein
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Fused in Sarcoma (FUS) (AA 287-376) protein (His-IF2DI Tag)
FUS Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB
Fused in Sarcoma (FUS) (AA 1-526) protein (His tag)Crystallography grade FUS Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
Fused in Sarcoma (FUS) (AA 1-518) protein (His tag)Crystallography grade FUS Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
Fused in Sarcoma (FUS) protein (Myc-DYKDDDDK Tag)FUS Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Fused in Sarcoma (FUS) (AA 27-529) protein (His tag)FUS Origin: Human respiratory syncytial virus A Host: Yeast Recombinant > 90 % SDS
Fused in Sarcoma (FUS) (AA 136-608) protein (His-SUMO Tag)FUS Origin: Canine Distemper Virus (CDV) Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Fused in Sarcoma (FUS) (AA 1-198), (partial) protein (GST tag)FUS Origin: Human Host: Escherichia coli (E. coli) Recombinant 95 % ELISA
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- FUS (Fused in Sarcoma (FUS))
- Alternative Name
- FUS (FUS Products)
- Target Type
- Viral Protein
- Background
- During virus entry, induces fusion of viral and cellular mbranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participates in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma mbrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.
- Molecular Weight
- 50.11 kDa
- UniProt
- O36634
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