RIPK3 Protein (AA 1-486, full length) (His tag)
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- Target See all RIPK3 Proteins
- RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-486, full length
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Origin
- Mouse
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Source
- Yeast
- Purification tag / Conjugate
- This RIPK3 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MSSVKLWPTG ASAVPLVSRE ELKKLEFVGK GGFGVVFRAH HRTWNHDVAV KIVNSKKISW EVKAMVNLRN ENVLLLLGVT EDLQWDFVSG QALVTRFMEN GSLAGLLQPE CPRPWPLLCR LLQEVVLGMC YLHSLNPPLL HRDLKPSNIL LDPELHAKLA DFGLSTFQGG SQSGSGSGSG SRDSGGTLAY LDPELLFDVN LKASKASDVY SFGILVWAVL AGREAELVDK TSLIRETVCD RQSRPPLTEL PPGSPETPGL EKLKELMIHC WGSQSENRPS FQDCEPKTNE VYNLVKDKVD AAVSEVKHYL SQHRSSGRNL SAREPSQRGT EMDCPRETMV SKMLDRLHLE EPSGPVPGKC PERQAQDTSV GPATPARTSS DPVAGTPQIP HTLPFRGTTP GPVFTETPGP HPQRNQGDGR HGTPWYPWTP PNPMTGPPAL VFNNCSEVQI GNYNSLVAPP RTTASSSAKY DQAQFGRGRG WQPFHK
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product RIPK3 Protein
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Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 1-518) protein (GST tag)
RIPK3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA, KAA
Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 418-518) protein (GST tag)RIPK3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 1-518) protein (Strep Tag)Crystallography grade RIPK3 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 1-486) protein (Strep Tag)Crystallography grade RIPK3 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Receptor-Interacting serine-threonine Kinase 3 (RIPK3) protein (GST tag)RIPK3 Origin: Human Host: Insect cells (Sf9) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Receptor-Interacting serine-threonine Kinase 3 (RIPK3) proteinRIPK3 Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, ELISA, IP
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))
- Alternative Name
- RIPK3 (RIPK3 Products)
- Synonyms
- RIPK3 Protein, RIP3 Protein, 2610528K09Rik Protein, AW107945 Protein, Rip3 Protein, Hcyp2 Protein, receptor interacting serine/threonine kinase 3 Protein, receptor interacting serine/threonine kinase 3 S homeolog Protein, receptor-interacting serine-threonine kinase 3 Protein, RIPK3 Protein, ripk3.S Protein, Ripk3 Protein
- Background
- Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family mbers. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
- Molecular Weight
- 55.32 kDa
- UniProt
- Q9QZL0
- Pathways
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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