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INHBA Protein (His tag)

INHBA Origin: Human Host: Tobacco (Nicotiana benthamiana) Recombinant > 97 % by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue. WB
Catalog No. ABIN573783
  • Target See all INHBA Proteins
    INHBA (Inhibin, beta A (INHBA))
    Protein Type
    Recombinant
    Origin
    • 10
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Human
    Source
    • 15
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Tobacco (Nicotiana benthamiana)
    Purification tag / Conjugate
    This INHBA protein is labelled with His tag.
    Application
    Western Blotting (WB)
    Characteristics
    Serological Identification: The protein was electrophoresed under reducing condition on a 15 % SDS-polyacrylamide gel, transferred by electroblotting to a NC membrane and visualized by immune-detection with specific antibody Activin A.
    Molecular formula: C600H911N173O174S13.
    Isoelectric Point: 7,27.
    Extinction coefficient: E 0.1 % (1g/L) = 1.27 (A 280 nm).
    This product contains no animal-derived components or impurities. It is produced by transient expression of TGF-beta2 in non-transgenic plants.
    Purification
    Recombinant human TGF-beta2 contains a 6-His-tag at the N-terminal end and is purified by sequential chromatography (FPLC).
    Purity
    > 97 % by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.
    Endotoxin Level
    < 0.04 EU/µg protein (LAL method)
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Lyophilized protein should be reconstituted in water to a concentration of 50 ng/µL. Due to the protein nature, dimmers and multimers may be observed.
    Concentration
    50 ng/µL
    Buffer
    Tris HCl 0.05 M buffer at pH 7.4
    Storage
    4 °C
  • Target
    INHBA (Inhibin, beta A (INHBA))
    Alternative Name
    INHBA (INHBA Products)
    Synonyms
    EDF Protein, FRP Protein, actba Protein, inhba Protein, inhbaa-001 Protein, edf Protein, frp Protein, INHB Protein, inhbal Protein, zgc:158348 Protein, inhibin beta A subunit Protein, inhibin beta-A Protein, inhibin, beta Aa Protein, inhibin beta A Protein, inhibin, beta Ab Protein, INHBA Protein, Inhba Protein, inhbaa Protein, inhba Protein, inhbab Protein
    Background
    Synonyms: Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein
    Activins are homodimers or heterodimers of the various beta subunit isoforms, belonging to the TGF-beta family. Mature Activin A has two 116 amino acids residues betaA subunits (betaA-betaA). Activin exhibits a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins plays a key role in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells known to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells. As with other members of the super-family, Activins interact with two types of cell surface trans-membrane receptors (Types I and II) which have intrinsic serine/threonine kinase activities in their cytoplasmic domains, Activin type 1 receptors, ACVR1, ACVR1B, ACVR1C and Activin type 2 receptors, ACVR2A, ACVR2B. The biological activity of Activin A can be neutralized by inhibins and by the diffusible TGF-B antagonist, Follistatin.
    Molecular Weight
    27.4 kDa
    Gene ID
    3624, 147290
    UniProt
    P05112
    Pathways
    Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Autophagy
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