GCHFR Protein (AA 1-84) (His tag)
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- Target See all GCHFR Proteins
- GCHFR (GTP Cyclohydrolase I Feedback Regulator (GCHFR))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-84
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This GCHFR protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSMPYLLIS TQIRMEVGPT MVGDEQSDPE LMQHLGASKR RALGNNFYEY YVDDPPRIVL DKLERRGFRV LSMTGVGQTL VWCLHKE
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product GCHFR Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.15M NaCl, 40 % glycerol, 1 mM DTT
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- GCHFR (GTP Cyclohydrolase I Feedback Regulator (GCHFR))
- Alternative Name
- GCHFR (GCHFR Products)
- Synonyms
- GFRP Protein, HsT16933 Protein, P35 Protein, 2010323F13Rik Protein, GTP cyclohydrolase I feedback regulator Protein, GCHFR Protein, Gchfr Protein
- Background
- GTP cyclohydrolase I feedback regulatory protein(GCHFR) binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. Recombinant human GCHFR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molecular Weight
- 12.1 kDa (107aa) confirmed by MALDI-TOF
- NCBI Accession
- NP_005249
- UniProt
- P30047
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