CAMLG Protein (AA 1-189) (His tag)
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- Target See all CAMLG Proteins
- CAMLG (Calcium Modulating Ligand (CAMLG))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-189
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CAMLG protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSMESMAVA TDGGERPGVP AGSGLSASQR RAELRRRKLL MNSEQRINRI MGFHRPGSGA EEESQTKSKQ QDSDKLNSLS VPSVSKRVVL GDSVSTGTTD QQGGVAEVKG TQLGDKLDSF IKPPECSSDV NLELRQRNRG DLTADSVQRG SRHGLEQYLS RFEEAMKLRK QLISEKPSQE DGNTTEEFDS FR
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product CAMLG Protein
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Calcium Modulating Ligand (CAMLG) (AA 1-189) protein (His tag)
CAMLG Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Calcium Modulating Ligand (CAMLG) (AA 1-296) protein (GST tag)CAMLG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Calcium Modulating Ligand (CAMLG) (AA 1-100) protein (GST tag)CAMLG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Calcium Modulating Ligand (CAMLG) (AA 1-296) protein (Strep Tag)Crystallography grade CAMLG Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Calcium Modulating Ligand (CAMLG) (AA 1-294) protein (Strep Tag)Crystallography grade CAMLG Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Calcium Modulating Ligand (CAMLG) protein (Myc-DYKDDDDK Tag)CAMLG Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.15M NaCl, 10 % glycerol
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- CAMLG (Calcium Modulating Ligand (CAMLG))
- Alternative Name
- CAMLG (CAMLG Products)
- Synonyms
- MGC53900 Protein, CAML Protein, AI385748 Protein, Camlg Protein, Caml Protein, calcium modulating ligand L homeolog Protein, calcium modulating ligand Protein, camlg.L Protein, CAMLG Protein, camlg Protein, Caml Protein, Camlg Protein
- Background
- The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. CAMLG functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. Recombinant human CAMLG protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molecular Weight
- 23.2 kDa (212aa), confirmed by MALDI-TOF
- NCBI Accession
- NP_001736
- UniProt
- P49069
- Pathways
- EGFR Signaling Pathway
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