RAPSN Protein (AA 1-412) (His tag)
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- Target See all RAPSN Proteins
- RAPSN (Receptor-Associated Protein of The Synapse (RAPSN))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-412
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This RAPSN protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSMGQDQTK QQIEKGLQLY QSNQTEKALQ VWMKVLEKGS DLVGRFRVLG CLVTAHSEMG RYKEMLKFAV VQIDTARGLE DADFLLESYL NLARSNEKLC EFHKTISYCK TCLGLPGTRA GAQLGGQVSL SMGNAFLGLS LFQKALESFE KALRYAHNND DTMLECRVCC SLGSFYAQVK DYEKALFFPC KAAELVNDYG KGWSLKYRAM SQYHMAVAYR LLGHLGSAME CCEESMKIAL QHGDRPLQAL CLLCFADIHR SRGDLETAFP RYDSAMSIMT EIGNRLGQVH VLLGVAKCWM ARKVQDKALD AIEKAQDLAE EVGNKLSQLK LHCLSESIYR SKGLQRELRT HVVRFHECVE ETELYCGLCG ESIGERNSRL QALPCSHIFH LRCLQNNGTR SCPNCRRSSM KPGFV
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product RAPSN Protein
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Receptor-Associated Protein of The Synapse (RAPSN) (AA 1-353) protein (GST tag)
RAPSN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Receptor-Associated Protein of The Synapse (RAPSN) (AA 313-412) protein (GST tag)RAPSN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Receptor-Associated Protein of The Synapse (RAPSN) (AA 2-412) protein (His tag)Crystallography grade RAPSN Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Receptor-Associated Protein of The Synapse (RAPSN) (AA 2-412) protein (His tag)Crystallography grade RAPSN Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Receptor-Associated Protein of The Synapse (RAPSN) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)RAPSN Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Denatured
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. 20 mM Tris-HCl buffer ( pH 8.0) containing 10 % glycerol 0.4M urea
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- RAPSN (Receptor-Associated Protein of The Synapse (RAPSN))
- Alternative Name
- RAPSN (RAPSN Products)
- Synonyms
- RAPSN Protein, RAPSYN Protein, RNF205 Protein, 43kDa Protein, Nraps Protein, Raps Protein, rapsyn Protein, receptor associated protein of the synapse Protein, receptor associated protein of the synapse S homeolog Protein, receptor-associated protein of the synapse Protein, receptor-associated protein of the synapse, 43kD Protein, RAPSN Protein, rapsn.S Protein, Rapsn Protein, rapsn Protein
- Background
- 43 kDa receptor-associated protein of the synapse, also known as RAPSN, is expressed in the postsynaptic membrane of skeletal muscle. RAPSN is required for the clustering of nicotinic acetylcholine receptors (nAChR). It self-associates through at least two of its seven tetra-tricopeptide repeats (TPRs). RAPSN interacts with the large intracellular domain of the nAChR a subunit through the hydrophobic surface of the coiled-coil domain. This protein modifies trafficking of AChR within the cell. Overexpression inhibits agrin-induced AChR clustering pathway. Recombinant human RAPSN protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molecular Weight
- 48.8 kDa (435aa)
- NCBI Accession
- NP_033049
- UniProt
- P12672
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