COPS7A Protein (AA 1-275) (His tag)
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- Target See all COPS7A Proteins
- COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-275
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This COPS7A protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSMSAEVKV TGQNQEQFLL LAKSAKGAAL ATLIHQVLEA PGVYVFGELL DMPNVRELAE SDFASTFRLL TVFAYGTYAD YLAEARNLPP LTEAQKNKLR HLSVVTLAAK VKCIPYAVLL EALALRNVRQ LEDLVIEAVY ADVLRGSLDQ RNQRLEVDYS IGRDIQRQDL SAIARTLQEW CVGCEVVLSG IEEQVSRANQ HKEQQLGLKQ QIESEVANLK KTIKVTTAAA AAATSQDPEQ HLTELREPAP GTNQRQPSKK ASKGKGLRGS AKIWSKSN
- Purity
- > 80 % by SDS - PAGE
- Top Product
- Discover our top product COPS7A Protein
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COP9 Signalosome Complex Subunit 7a (COPS7A) (AA 1-275) protein (GST tag)
COPS7A Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
COP9 Signalosome Complex Subunit 7a (COPS7A) (AA 2-275) protein (His tag)Crystallography grade COPS7A Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
COP9 Signalosome Complex Subunit 7a (COPS7A) (AA 2-275) protein (His tag)Crystallography grade COPS7A Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
COP9 Signalosome Complex Subunit 7a (COPS7A) (AA 2-275) protein (His-SUMO Tag)COPS7A Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
COP9 Signalosome Complex Subunit 7a (COPS7A) protein (Myc-DYKDDDDK Tag)COPS7A Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Denatured
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.4M urea, 10 % glycerol
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))
- Alternative Name
- COPS7A (COPS7A Products)
- Synonyms
- D6Ertd35e Protein, CSN7A Protein, COP9 signalosome subunit 7A Protein, COPS7A Protein, Cops7a Protein
- Background
- COPS7A is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JuN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JuN promotes and protects degradation by the ubl system, respectively. Recombinant human COPS7A protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molecular Weight
- 32.7 kDa (298aa)
- NCBI Accession
- NP_001157566
- UniProt
- Q9UBW8
- Pathways
- Cell Division Cycle
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