ZFAND5 Protein (AA 1-213) (His tag)

Catalog No. ABIN5854034

Product Details

Target: ZFAND5 (Zinc Finger, AN1-Type Domain 5 (ZFAND5))

Protein Type: Recombinant

Protein Characteristics: AA 1-213

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This ZFAND5 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAQETNQ TPGPMLCSTG CGFYGNPRTN GMCSVCYKEH LQRQQNSGRM SPMGTASGSN SPTSDSASVQ RADTSLNNCE GAAGSTSEKS RNVPVAALPV TQQMTEMSIS REDKITTPKT EVSEPVVTQP SPSVSQPSTS QSEEKAPELP KPKKNRCFMC RKKVGLTGFD CRCGNLFCGL HRYSDKHNCP YDYKAEAAAK IRKENPVVVA EKIQRI

Purity: > 85 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Phosphate buffer saline (  pH 8.0) containing 30 % glycerol, 1  mM DTT

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: ZFAND5 (Zinc Finger, AN1-Type Domain 5 (ZFAND5))

Alternative Name: ZFAND5 (ZFAND5 Products)

Synonyms: 2310057A04Rik Protein, 5830475F03Rik Protein, AA415485 Protein, Za20d2 Protein, Zfp216 Protein, ZA20D2 Protein, ZFAND5A Protein, ZNF216 Protein, wu:fi29f06 Protein, za20d2l Protein, zgc:56057 Protein, za20d2 Protein, zfand5 Protein, zfand5-a Protein, zfand5-b Protein, zfand5a Protein, znf216 Protein, id:ibd2892 Protein, wu:fb16d02 Protein, wu:fc67h07 Protein, zgc:73363 Protein, zinc finger, AN1-type domain 5 Protein, zinc finger AN1-type containing 5 Protein, zinc finger, AN1-type domain 5b Protein, zinc finger AN1-type containing 5 L homeolog Protein, zinc finger, AN1-type domain 5a Protein, Zfand5 Protein, ZFAND5 Protein, zfand5b Protein, zfand5.L Protein, zfand5a Protein

Background: ZFAND5 is involved in protein degradation via the ubiquitin-proteasome system. This protein may act by anchoring ubiquitinated proteins to the proteasome and plays a role in ubiquitin-mediated protein degradation during muscle atrophy. ZFAND5 plays a role in the regulation of NF-kappa-B activation and apoptosis and inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. It inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Recombinant human ZFAND5 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molecular Weight: 25.5 kDa (236aa) confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)

NCBI Accession: NP_005998

UniProt: O76080

Pathways: Platelet-derived growth Factor Receptor Signaling