JAM2 Protein (AA 29-238) (hIgG-His-tag)

Catalog No. ABIN5855110

Product Details

Target: JAM2 (Junctional Adhesion Molecule 2 (JAM2))

Protein Type: Recombinant

Protein Characteristics: AA 29-238

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This JAM2 protein is labelled with hIgG-His-tag.

Application: SDS-PAGE (SDS)

Sequence: ADPEYSNCGE NEYYNQTTGL CQECPPCGPG EEPYLSCGYG TKDEDYGCVP CPAEKFSKGG YQICRRHKDC EGFFRATVLT PGDMENDAEC GPCLPGYYML ENRPRNIYGM VCYSCLLAPP NTKECVGATS GASANFPGTS GSSTLSPFQH AHKELSGQGH LATAAAAFES RACSLEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH

Purity: > 90 % by SDS - PAGE

Endotoxin Level: < 1.0 EU per 1ug of protein (determined by LAL method)

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: JAM2 (Junctional Adhesion Molecule 2 (JAM2))

Alternative Name: JAM2 (JAM2 Products)

Synonyms: JAM2 Protein, cd322 Protein, jam-b Protein, jamb Protein, pro245 Protein, ve-jam Protein, vejam Protein, jam2 Protein, sb:cb1002 Protein, im:7155552 Protein, sc:d0813 Protein, si:ch211-160b11.5 Protein, LOC100227766 Protein, 1110002N23Rik Protein, 2410030G21Rik Protein, 2410167M24Rik Protein, JAM-2 Protein, JAM-B Protein, Jcam2 Protein, VE-JAM Protein, C21orf43 Protein, CD322 Protein, JAMB Protein, PRO245 Protein, VEJAM Protein, junctional adhesion molecule 2 Protein, junctional adhesion molecule 2a Protein, junctional adhesion molecule 2b Protein, junction adhesion molecule 2 Protein, JAM2 Protein, jam2 Protein, jam2a Protein, jam2b Protein, Jam2 Protein

Background: EDAR, also known as tumor necrosis factor receptor superfamily member EDAR, is a single-pass type 1 transmembrane protein which is a member of TNF receptor superfamily. This protein was expressed reiteratively in signaling centers regulating key steps in morphogenesis. Also, it is a cell surface receptor for ectodysplasin A which plays an important role in the development of ectodermal tissues such as the skin. Also, defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA), also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structure. Recombinant human EDAR, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Molecular Weight: 45.6kDa (413aa) 40-57kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_071731

UniProt: Q9UNE0