KAP1 Protein (AA 22-291, partial) (GST tag)
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- Target See all KAP1 (TRIM28) Proteins
- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-291, partial
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This KAP1 protein is labelled with GST tag.
- Application
- SDS-PAGE (SDS), Western Blotting (WB), ELISA, Particle-Enhanced Turbidimetric Assay (PETIA)
- Sequence
- PGEGSAGGEK RSTAPSAAAS ASASAAASSP AGGGAEALEL LEHCGVCRER LRPEREPRLL PCLHSACSAC LGPAAPAAAN SSGDGGAAGD GTVVDCPVCK QQCFSKDIVE NYFMRDSGSK AATDAQDANQ CCTSCEDNAP ATSYCVECSE PLCETCVEAH QRVKYTKDHT VRSTGPAKSR DGERTVYCNV HKHEPLVLFC ESCDTLTCRD CQLNAHKDHQ YQFLEDAVRN QRKLLASLVK RLGDKHATLQ KSTKEVRSSI RQVSDVQKRV
- Purity
- 90 %
- Top Product
- Discover our top product TRIM28 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS buffer, 20mM GSH
- Storage
- 4 °C
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- Target
- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
- Alternative Name
- Transcription intermediary factor 1-beta (TRIM28 Products)
- Synonyms
- KAP1 Protein, RNF96 Protein, TF1B Protein, TIF1B Protein, TRIM28 Protein, kap1 Protein, rnf96 Protein, tf1b Protein, tif1b Protein, AA408787 Protein, KAP-1 Protein, KRIP-1 Protein, Tif1b Protein, Tif1beta Protein, Kap1 Protein, Krip1 Protein, TIF1BETA Protein, tripartite motif containing 28 Protein, tripartite motif containing 28 L homeolog Protein, tripartite motif-containing 28 Protein, TRIM28 Protein, trim28.L Protein, Trim28 Protein
- Background
- Background: Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Synonyms: E3 SUMO-protein ligase TRIM28 EC=6.3.2.- KRAB-associated protein 1 Short name=KAP-1 KRAB-interacting protein 1 Short name=KRIP-1 Nuclear corepressor KAP-1 RING finger protein 96 Tripartite motif-containing protein 28.
- Molecular Weight
- 56.1 kD
- NCBI Accession
- NM_005762
- UniProt
- Q13263
- Pathways
- Hedgehog Signaling, Positive Regulation of Response to DNA Damage Stimulus
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