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IL21 Receptor Protein (AA 20-234) (Fc Tag)

IL21R Origin: Mouse Host: CHO Cells Recombinant >98 % (SDS-PAGE)
Catalog No. ABIN6253264
  • Target See all IL21 Receptor (IL21R) Proteins
    IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 20-234
    Origin
    • 14
    • 8
    • 2
    • 1
    Mouse
    Source
    • 13
    • 5
    • 3
    • 2
    • 1
    • 1
    CHO Cells
    Purification tag / Conjugate
    This IL21 Receptor protein is labelled with Fc Tag.
    Purpose
    IL-21R (mouse):Fc (mouse) (rec.) (non-lytic)
    Specificity
    The extracellular domain of mouse IL-21R (aa 20-234) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.
    Characteristics
    Protein. The extracellular domain of mouse IL-21R (aa 20-234) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. Complex formation between IL-21R and the common gamma chain (gammac) is required for signaling. IL-21R is expressed mainly on B cells (highest on mature, activated, follicular and germinal center B cells), NK cells and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells and keratinocytes. B cell IL-21R engagement induces Blimp1 (which mediates plasma cell differentiation) and is important for memory responses. IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-gamma production. IL-21R engagement on CD8+ T cells aids control of viral infection and tumor growth, IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. IL-21R expression is often upregulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL).
    Purity
    >98 % (SDS-PAGE)
    Endotoxin Level
    <0.06EU/μg protein (LAL test, Lonza).
    Biological Activity Comment
    Shows the biological function of the IL-21R moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
    Top Product
    Discover our top product IL21R Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Lot specific
    Buffer
    Lyophilized from 0.2μm-filtered solution in PBS.
    Handling Advice
    Avoid freeze/thaw cycles.
    Storage
    4 °C,-20 °C
    Storage Comment

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

  • Target
    IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
    Alternative Name
    IL-21R (IL21R Products)
    Synonyms
    IL21R Protein, il-21ra.a Protein, CD360 Protein, NILR Protein, interleukin 21 receptor Protein, interleukin 21 receptor, tandem duplicate 1 Protein, IL21R Protein, il21r.1 Protein, Il21r Protein
    Background

    Alternate Names/Synonyms: Interleukin-21 Receptor, CD360, NILR

    Product Description: Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. Complex formation between IL-21R and the common gamma chain (gammac) is required for signaling. IL-21R is expressed mainly on B cells (highest on mature, activated, follicular and germinal center B cells), NK cells and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells and keratinocytes. B cell IL-21R engagement induces Blimp1 (which mediates plasma cell differentiation) and is important for memory responses. IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-gamma production. IL-21R engagement on CD8+ T cells aids control of viral infection and tumor growth, IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. IL-21R expression is often upregulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL).

    Pathways
    JAK-STAT Signaling
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