CD83 Protein (CD83) (AA 20-131) (Fc Tag)
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- Target See all CD83 Proteins
- CD83
- Protein Type
- Recombinant
- Protein Characteristics
- AA 20-131
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Origin
- Human
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Source
- CHO Cells
- Purification tag / Conjugate
- This CD83 protein is labelled with Fc Tag.
- Purpose
- CD83 (human):Fc (human) (rec.) (non-lytic)
- Specificity
- The extracellular domain of human CD83 (aa 20-131) is fused to the N-terminus of the Fc region of a mutant human IgG1.
- Characteristics
- Protein. The extracellular domain of human CD83 (aa 20-131) is fused to the N-terminus of the Fc region of a mutant human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Human CD83 is a 40-50 kDa member of the Siglec (or sialic-acid-binding immunoglobulin-like lectin) family of transmembrane proteins. CD83 is a primary marker for dendritic cells. It is also found on B cells, neutrophils, monocytes and macrophages. Except for dendritic cells, CD83 expression is often transient. CD83 binds to sialic acids on target cells. Membrane CD83 promotes T cell proliferation, particularly of CD8+ cytotoxic T cells. Soluble CD83 is immunosuppressive and blocks T cell activation. On monocytes, CD83 is suggested to drive monocytes into a fibrocyte phenotype. A lack of membrane-expressed CD83 leads to an unusual IL-4/ IL-10 producing CD4+ T cell phenotype.
- Purity
- >98 % (SDS-PAGE)
- Endotoxin Level
- <0.06EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- Shows the biological function of the CD83 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
- Top Product
- Discover our top product CD83 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- Avoid freeze/thaw cycles.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- CD83
- Alternative Name
- CD83 (CD83 Products)
- Synonyms
- BL11 Protein, HB15 Protein, CD83 molecule Protein, CD83 antigen Protein, Cd83 Protein, CD83 Protein
- Background
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Product Description: Human CD83 is a 40-50 kDa member of the Siglec (or sialic-acid-binding immunoglobulin-like lectin) family of transmembrane proteins. CD83 is a primary marker for dendritic cells. It is also found on B cells, neutrophils, monocytes and macrophages. Except for dendritic cells, CD83 expression is often transient. CD83 binds to sialic acids on target cells. Membrane CD83 promotes T cell proliferation, particularly of CD8+ cytotoxic T cells. Soluble CD83 is immunosuppressive and blocks T cell activation. On monocytes, CD83 is suggested to drive monocytes into a fibrocyte phenotype. A lack of membrane-expressed CD83 leads to an unusual IL-4/ IL-10 producing CD4+ T cell phenotype.
- NCBI Accession
- NP_004224
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