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VTCN1 Protein (AA 29-258) (Fc Tag)

VTCN1 Origin: Mouse Host: CHO Cells Recombinant >98 % (SDS-PAGE)
Catalog No. ABIN6253362
  • Target See all VTCN1 Proteins
    VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 29-258
    Origin
    • 27
    • 6
    • 5
    • 3
    • 2
    • 1
    Mouse
    Source
    • 27
    • 6
    • 6
    • 1
    • 1
    • 1
    CHO Cells
    Purification tag / Conjugate
    This VTCN1 protein is labelled with Fc Tag.
    Purpose
    B7-H4 (mouse):Fc (mouse) (rec.)
    Specificity
    The extracellular domain of mouse B7-H4 (aa 29-258) is fused to the N-terminus of the Fc region of mouse IgG2a.
    Characteristics
    Protein. The extracellular domain of mouse B7-H4 (aa 29-258) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.
    Purity
    >98 % (SDS-PAGE)
    Endotoxin Level
    <0.06EU/μg protein (LAL test, Lonza).
    Biological Activity Comment
    Measured by its ablility to inhibit anti-CD3-induced proliferation of stimulated mouse T cells.
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    Discover our top product VTCN1 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Lot specific
    Buffer
    Lyophilized from 0.2μm-filtered solution in PBS.
    Handling Advice
    Avoid freeze/thaw cycles.
    Storage
    4 °C,-20 °C
    Storage Comment

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

  • Target
    VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))
    Alternative Name
    B7-H4 (VTCN1 Products)
    Synonyms
    B7h4 Protein, B7s1 Protein, B7x Protein, BC032925 Protein, B7-H4 Protein, B7H4 Protein, B7S1 Protein, B7X Protein, B7h.5 Protein, PRO1291 Protein, VCTN1 Protein, RGD1311204 Protein, V set domain containing T cell activation inhibitor 1 L homeolog Protein, V-set domain containing T cell activation inhibitor 1 Protein, V-set domain containing T-cell activation inhibitor 1 Protein, V set domain containing T cell activation inhibitor 1 Protein, vtcn1.L Protein, VTCN1 Protein, vtcn1 Protein, Vtcn1 Protein
    Background

    Alternate Names/Synonyms: V-set Domain-containing T Cell Activation Inhibitor 1, VTCN1, B7h.5, Immune Costimulatory Protein B7-H4, T Cell Costimulatory Molecule B7x, Protein B7S1

    Product Description: B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.

    NCBI Accession
    NP_848709
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