Crk Protein (AA 1-204) (His tag)

Catalog No. ABIN6386629

Product Details

Target: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Protein Type: Recombinant

Protein Characteristics: AA 1-204

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Crk protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: CRK, 1-204aa, Human, His tag, E.coli

Purity: > 95 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol

Storage: 4 °C

Target Details

Target: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Alternative Name: CRK (CRK Products)

Synonyms: CG1587 Protein, CRK Protein, D-CRK Protein, D-Crk Protein, DCrk Protein, Dcrk Protein, Dmel\\CG1587 Protein, crk Protein, dCRK Protein, dCrk Protein, fb34h10 Protein, fc05a01 Protein, fi19g05 Protein, wu:fb34h10 Protein, wu:fc05a01 Protein, wu:fc54a04 Protein, wu:fi19g05 Protein, zgc:100936 Protein, CRKII Protein, p38 Protein, Crko Protein, crk2 Protein, crkII Protein, v-crk Protein, P38C-CRK Protein, Crk-I Protein, Crk-II Protein, Crk-III Protein, Crk3 Protein, CrkIII Protein, c-Crk Protein, Crk oncogene Protein, v-crk avian sarcoma virus CT10 oncogene homolog Protein, CRK proto-oncogene, adaptor protein Protein, v-crk avian sarcoma virus CT10 oncogene homolog L homeolog Protein, v-crk sarcoma virus CT10 oncogene homolog Protein, Crk Protein, crk Protein, CRK Protein, crk.L Protein

Background: CRK is a member of signaling adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein is involved in many cellular processes including apoptosis, proliferation, and differentiation. It has a modular domain architecture consisting of an SH2 followed by two SH3 domains (src-homology domains). The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Recombinant human CRK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Adapter molecule crk, Proto-oncogene c-Crk, p38, CRKII. NCBI no.: NP_005197

Molecular Weight: 25.0 kDa (224aa), confirmed by MALDI-TOF

Pathways: Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor