STUB1 Protein (AA 1-303)

Catalog No. ABIN666729

Product Details

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Protein Type: Recombinant

Protein Characteristics: AA 1-303

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Characteristics: CHIP, 1-303aa, Human, Recombinant, E.coli

Purity: > 90 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 5 mM DTT, 10% glycerol

Storage: 4 °C

Target Details

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Alternative Name: CHIP (STUB1 Products)

Synonyms: CHIP Protein, HSPABP2 Protein, NY-CO-7 Protein, SDCCAG7 Protein, UBOX1 Protein, 0610033N24Rik Protein, 2210017D18Rik Protein, 2310040B03Rik Protein, AW046544 Protein, Chip Protein, wu:fc22f04 Protein, zgc:56076 Protein, STUB1 Protein, chip Protein, ATCHIP Protein, CARBOXYL TERMINUS OF HSC70-INTERACTING PROTEIN Protein, carboxyl terminus of HSC70-interacting protein Protein, STIP1 homology and U-box containing protein 1 Protein, STIP1 homology and U-Box containing protein 1 Protein, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase L homeolog Protein, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase Protein, STIP1 homology and U box-containing protein 1 Protein, carboxyl terminus of HSC70-interacting protein Protein, STUB1 Protein, Stub1 Protein, stub1 Protein, stub1.L Protein, LOC100282870 Protein, CHIP Protein

Background: CHIP, also known as STUB1, is a cytoplasmic protein whose amino acid sequence is highly conserved across species. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, whereas its U-box domain contains its E3 ubiquitin ligase activity. Its interaction with these molecular chaperones results in client substrate ubiquitylation and degradation by the proteasome. Thus, CHIP acts to tilt the folding-refolding machinery toward the degradative pathway, and it serves as a link between the two. Recombinant human CHIP protein was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: STUB1, HSPABP2, NY-CO-7, SDCCAG7, UBOX1 , Carboxy terminus of HSP70 interacting protein Antigen NY CO 7, CLL associated antigen KW 8, Carboxy terminus of Hsp70p interacting protein, CHIP, E3 ubiquitin protein ligase CHIP, STUB 1, UBOX 1, Heat shock protein A binding protein 2 (c terminal), NY CO 7, Serologically defined colon cancer antigen 7, STIP1 homology and U Box containing protein 1. NCBI no.: NP_005852

Molecular Weight: 34.8 kDa (303 aa), confirmed by MALDI-TOF.

Pathways: Regulation of Hormone Metabolic Process, Response to Water Deprivation