PDIA3 Protein (AA 25-505) (His tag)

Catalog No. ABIN666935

Product Details

Target: PDIA3 (Protein Disulfide Isomerase Family A, Member 3 (PDIA3))

Protein Type: Recombinant

Protein Characteristics: AA 25-505

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This PDIA3 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: PDIA3, 25-505aa, Human, His tag, E.coli

Purity: > 95 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 0.1 M NaCl, and 10% glycerol

Storage: 4 °C

Target Details

Target: PDIA3 (Protein Disulfide Isomerase Family A, Member 3 (PDIA3))

Alternative Name: PDIA3 (PDIA3 Products)

Synonyms: ER60 Protein, ERp57 Protein, ERp60 Protein, ERp61 Protein, GRP57 Protein, GRP58 Protein, HsT17083 Protein, P58 Protein, PI-PLC Protein, grp-58 Protein, 58kDa Protein, Erp Protein, Grp58 Protein, PDI Protein, PDI-Q2 Protein, PLC[a] Protein, Plca Protein, 1 Protein, 25D3-membrane-associated Protein, sb:cb825 Protein, erp57 Protein, grp58 Protein, pdia3 Protein, protein disulfide isomerase family A member 3 Protein, protein disulfide-isomerase A3 Protein, protein disulfide isomerase associated 3 Protein, protein disulfide isomerase family A, member 3 Protein, protein disulfide isomerase family A member 3 S homeolog Protein, PDIA3 Protein, Tsp_10062 Protein, Pdia3 Protein, pdia3 Protein, pdia3.S Protein

Background: PDIA3, also known as protein disulfide-isomerase A3, is a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. This protein has protein disulfide isomerase activity. PDIA3 is also part of the major histocompatibility complex (MHC) class I peptide-loading complex (TAP1), which is essential for formation of the final antigen conformation and export from the endoplasmic reticulum to the cell surface. Recombinant human PDIA3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HsT17083, P58, PI-PLC, Protein disulfide-isomerase A3 58 kDa glucose regulated protein, 58 kDa microsomal protein, Disulfide isomerase ER 60, ER p57, ERp 57, Glucose Regulated Protein 58 Kd, GRP 57, GRP 58, HsT17083, PDIA 3, PDIA3, Phospholipase C alpha, PI PLC, Protein disulfide isomerase A3, Protein disulfide isomerase family A member 3. NCBI no.: NP_005304

Molecular Weight: 58.5 kDa (518aa), confirmed by MALDI-TOF.

Pathways: Maintenance of Protein Location, Protein targeting to Nucleus, Cell RedoxHomeostasis