MMAB Protein (AA 33-250) (His tag)

Catalog No. ABIN667185

Product Details

Target: MMAB (Methylmalonic Aciduria (Cobalamin Deficiency) CblB Type (MMAB))

Protein Type: Recombinant

Protein Characteristics: AA 33-250

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This MMAB protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: MMAB, 33-250aa, Human, His tag, E.coli

Purity: > 95 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 10% Glycerol

Storage: 4 °C

Target Details

Target: MMAB (Methylmalonic Aciduria (Cobalamin Deficiency) CblB Type (MMAB))

Alternative Name: MMAB (MMAB Products)

Synonyms: ATR Protein, cblB Protein, cob Protein, 9130222L19Rik Protein, methylmalonic aciduria (cobalamin deficiency) cblB type Protein, methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human) Protein, MMAB Protein, Mmab Protein

Background: MMAB is a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12 containing coenzyme for methylmalonyl-CoA mutase(MCM). Impaired MMAB activity leads to the inherited disorder vitamin B12 dependent methylmalonic aciduria linked to the cblB complementation group. Recombinant human MMAB protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: ATR, ATP:cob(I)alamin adenosyltransferase, Methylmalonic aciduria (cobalamin deficiency) cblB type. NCBI no.: AAH05054

Molecular Weight: 26.3 kDa(239aa), confirmed by MALDI-TOF