Sntn Protein (AA 1-147) (His tag)
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- Target See all Sntn Proteins
- Sntn (Sentan, Cilia Apical Structure Protein (Sntn))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-147
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Sntn protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- SNTN, 1-147aa, Human, His tag, E.coli
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product Sntn Protein
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Sentan, Cilia Apical Structure Protein (Sntn) (AA 1-147) protein (His tag)
Sntn Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Sentan, Cilia Apical Structure Protein (Sntn) (AA 1-147) protein (Strep Tag)Crystallography grade Sntn Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Sentan, Cilia Apical Structure Protein (Sntn) protein (Myc-DYKDDDDK Tag)Sntn Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. 20mM Tris-HCl buffer (pH8.0) containing 50% glycerol, 0.15M NaCl, 1mM DTT
- Storage
- 4 °C
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- Target
- Sntn (Sentan, Cilia Apical Structure Protein (Sntn))
- Alternative Name
- SNTN (Sntn Products)
- Synonyms
- S100A1L Protein, S100AL Protein, sentan Protein, A430083B19Rik Protein, sentan, cilia apical structure protein Protein, SNTN Protein, Sntn Protein
- Background
- SNTN, also known as sentan, belongs to the S-100 family. SNTN is shown to localize exclusively to the bridging structure between the cell membrane and peripheral singlet microtubules, which specifically exists in the narrowed distal portion of cilia. Exogenously expressed sentan showed affinity for the membrane protrusions, and a protein-lipid binding assay revealed that sentan bound to phosphatidylserine. These findings suggest that sentan is the first molecular component of the ciliary tip to bridge the cell membrane and peripheral singlet microtubules, making the distal portion of the cilia narrow and stiff to allow for better airway clearance or ovum transport. Recombinant human SNTN protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Sentan, S100A1L, S100AL. NCBI no.: NP_001074006
- Molecular Weight
- 18.6 kDa (167aa), confirmed by MALDI-TOF
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