SCO2 Protein (AA 42-266) (His tag)
-
- Target See all SCO2 Proteins
- SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 42-266
-
Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This SCO2 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- SCO2, 42-266aa, Human, His tag, E.coli
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product SCO2 Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.5mg/ml (determined by Bradford assay)
- Buffer
- Liquid. 20mM Tris-HCl buffer (pH8.0) containing 30% glycerol, 2mM DTT, 200mM NaCl
- Storage
- 4 °C
-
- Target
- SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))
- Alternative Name
- SCO2 (SCO2 Products)
- Synonyms
- CEMCOX1 Protein, MYP6 Protein, SCO1L Protein, SCO cytochrome oxidase deficient homolog 2 (yeast) Protein, SCO2 cytochrome c oxidase assembly protein Protein, SCO2, cytochrome c oxidase assembly protein Protein, SCO2 Protein, Sco2 Protein
- Background
- SCO2 protein belongs to the SCO1/2 family of proteins. Both SCO1 and SCO2 proteins are located on the inner membrane of the mitochondria and plays a crucial role in copper insertion or transport to the active site of cytochrome c oxidase (COX). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Recombinant human SCO2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Protein SCO2 homolog mitochondrial, SCO1L. NCBI no.: NP_005129
- Molecular Weight
- 27.4kDa (246aa), confirmed by MALDI-TOF
- Pathways
- Transition Metal Ion Homeostasis, Warburg Effect
-