HSD17B8 Protein (AA 1-261) (His tag)
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- Target See all HSD17B8 Proteins
- HSD17B8 (Hydroxysteroid (17-Beta) Dehydrogenase 8 (HSD17B8))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-261
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This HSD17B8 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- HSD17B8, 1-261aa, Human, His tag, E.coli
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product HSD17B8 Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. 20mM Tris-HCl buffer (pH8.0) containing 40% glycerol, 150mM NaCl
- Storage
- 4 °C
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- Target
- HSD17B8 (Hydroxysteroid (17-Beta) Dehydrogenase 8 (HSD17B8))
- Alternative Name
- HSD17B8 (HSD17B8 Products)
- Synonyms
- KE6 Protein, fabgl Protein, zgc:112550 Protein, si:dz12f11.4 Protein, HKE6 Protein, FABGL Protein, ke6 Protein, fabg Protein, hke6 Protein, ring2 Protein, h2-ke6 Protein, d6s2245e Protein, D17H6S112E Protein, H-2Ke6 Protein, Hsd17b8 Protein, Ke-6 Protein, Ke6 Protein, Ring2 Protein, D6S2245E Protein, FABG Protein, H2-KE6 Protein, RING2 Protein, SDR30C1 Protein, dJ1033B10.9 Protein, Fabgl Protein, hydroxysteroid (17-beta) dehydrogenase 8 Protein, hydroxysteroid 17-beta dehydrogenase 8 Protein, H2-K region expressed gene 6 Protein, hsd17b8 Protein, HSD17B8 Protein, H2-Ke6 Protein, Hsd17b8 Protein
- Background
- HSD17B8, also known as estradiol 17-beta-dehydrogenase 8, belongs to the short-chain dehydrogenases/reductases (SDR) family. In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. It may play a role in biosynthesis of fatty acids in mitochondria. Recombinant human HSD17B8 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Estradiol 17-beta-dehydrogenase 8, FABGL, HKE6, RING2. NCBI no.: NP_055049
- Molecular Weight
- 29.1 kDa (281aa), confirmed by MALDI-TOF
- Pathways
- Steroid Hormone Biosynthesis
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