C5 Protein (AA 19-1676) (His tag)

Catalog No. ABIN6809857

Product Details

Target: C5 (Complement Component 5 (C5))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 19-1676

Origin: Cynomolgus

Source: HEK-293 Cells

Purification tag / Conjugate: This C5 protein is labelled with His tag.

Sequence: AA 19-1676

Purity: >95 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Target Details

Target: C5 (Complement Component 5 (C5))

Alternative Name: Complement C5 (C5 Products)

Synonyms: C5 Protein, LOC565774 Protein, C5a Protein, C5b Protein, CPAMD4 Protein, Hc Protein, RGD1561905 Protein, He Protein, complement C5 Protein, complement component 5 Protein, hemolytic complement Protein, C5 Protein, c5 Protein, Hc Protein

Background: Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Molecular Weight: 73.9 kDa (β chain) & 114.9 kDa (α chain)

NCBI Accession: XP_005580972

Pathways: Complement System, Carbohydrate Homeostasis