Insulin Receptor Protein (INSR) (AA 28-944) (His tag)
INSR
Origin: Human
Host: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
Active
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- Target See all Insulin Receptor (INSR) Proteins
- Insulin Receptor (INSR)
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 28-944
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Insulin Receptor protein is labelled with His tag.
- Sequence
- AA 28-944
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Insulin Receptor (INSR) (AA 881-980) protein (GST tag)
INSR Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Insulin Receptor (INSR) (Active) protein (GST tag,His tag)INSR Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 92 % as determined by reducing SDS-PAGE. Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- Insulin Receptor (INSR)
- Alternative Name
- Insulin R (INSR Products)
- Background
- Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.
- Molecular Weight
- 106.5 kDa
- NCBI Accession
- NP_000199
- Pathways
- NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
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