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PVRL4 Protein (AA 32-349) (His tag,AVI tag,Biotin)

PVRL4 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Catalog No. ABIN6938938
  • Target See all PVRL4 Proteins
    PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 32-349
    Origin
    • 23
    • 8
    • 2
    • 1
    • 1
    • 1
    Human
    Source
    • 21
    • 4
    • 4
    • 3
    • 2
    • 2
    HEK-293 Cells
    Purification tag / Conjugate
    This PVRL4 protein is labelled with His tag,AVI tag,Biotin.
    Sequence
    AA 32-349
    Specificity
    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
    Purity
    >95 % as determined by SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product PVRL4 Protein
  • Comment

    Ready-to-use AvitagTM biotinylated protein:
    The product is exclusively produced using the AvitagTM technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

    This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
  • Target
    PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))
    Alternative Name
    Nectin-4 (PVRL4 Products)
    Synonyms
    PVRL4 Protein, si:ch211-155e24.1 Protein, 1200017F15Rik Protein, Prr4 Protein, RGD1559826 Protein, EDSS1 Protein, LNIR Protein, PRR4 Protein, nectin-4 Protein, nectin cell adhesion molecule 4 Protein, NECTIN4 Protein, nectin4 Protein, Nectin4 Protein
    Background
    Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50 % , 49 % and 86 %o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.
    Molecular Weight
    37.8 kDa
    NCBI Accession
    NP_112178
    Pathways
    Cell-Cell Junction Organization
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