Macrophage Mannose Receptor 1 Protein (AA 19-1389) (His tag)
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- Target See all Macrophage Mannose Receptor 1 (MRC1) Proteins
- Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 19-1389
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Macrophage Mannose Receptor 1 protein is labelled with His tag.
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product MRC1 Protein
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Mannose Receptor, C Type 1 (MRC1) (AA 19-148) protein (His-IF2DI Tag)
MRC1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Mannose Receptor, C Type 1 (MRC1) (AA 22-130) protein (GST tag)MRC1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Mannose Receptor, C Type 1 (MRC1) (AA 19-1389) protein (His tag)Crystallography grade MRC1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Mannose Receptor, C Type 1 (MRC1) (AA 20-1388) protein (His tag)Crystallography grade MRC1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Mannose Receptor, C Type 1 (MRC1) (AA 19-1456) protein (rho-1D4 tag)Crystallography grade MRC1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Mannose Receptor, C Type 1 (MRC1) (AA 20-1456) protein (rho-1D4 tag)Crystallography grade MRC1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Mannose Receptor, C Type 1 (MRC1) (AA 655-1213) protein (His-SUMO Tag)MRC1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))
- Alternative Name
- CD206 (MRC1 Products)
- Synonyms
- CD206 Protein, CLEC13D Protein, CLEC13DL Protein, MMR Protein, MRC1L1 Protein, bA541I19.1 Protein, AW259686 Protein, MR Protein, mrc1 Protein, MGC86525 Protein, MRC1 Protein, MRC1L-A Protein, mannose receptor C-type 1 Protein, mannose receptor, C type 1 Protein, mannose receptor C-type 1 L homeolog Protein, mediator of replication checkpoint 1 Protein, MRC1 Protein, Mrc1 Protein, mrc1.L Protein, mrc1 Protein
- Background
- Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.
- Molecular Weight
- 158.6 kDa
- NCBI Accession
- NP_002429
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