SARS-CoV-2 Spike S1 Protein (RBD) (Fc Tag)
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- Target See all SARS-CoV-2 Spike S1 Proteins
- SARS-CoV-2 Spike S1
- Protein Type
- Recombinant
- Protein Characteristics
- RBD
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Origin
- SARS Coronavirus-2 (SARS-CoV-2)
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SARS-CoV-2 Spike S1 protein is labelled with Fc Tag.
- Sequence
- AA 319-541
- Characteristics
- 2019-nCoV (COVID-19) S protein RBD, Fc Tag (MALS verified) is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Phe 541 (Accession # QHD43416.1). Predicted N-terminus: Arg 319 This protein carries a human IgG1 Fc tag at the C-terminus.
- Purity
- > 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product SARS-CoV-2 Spike S1 Protein
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- Application Notes
- The protein has a calculated MW of 51.5 kDa. The protein migrates as 58-65 kDa under reducing (R) condition due to glycosylation.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C,-80 °C
- Storage Comment
- For long term storage, the product should be stored at lyophilized state at -20°C or lower. This product is stable aftr storage at: -20°C to -70°C for 12 months in lyophilized state, -70°C for 3 months under sterile conditions after reconstitution.
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- Target
- SARS-CoV-2 Spike S1
- Abstract
- SARS-CoV-2 Spike S1 Products
- Synonyms
- E2 Protein, Surface Glycoprotein Protein, S Protein
- Target Type
- Viral Protein
- Background
- It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
- Molecular Weight
- 51.5 kDa
- Gene ID
- 43740568
- UniProt
- P0DTC2
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