Poliovirus Receptor Protein (PVR) (AA 21-343) (mFc-His Tag)
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- Target See all Poliovirus Receptor (PVR) Proteins
- Poliovirus Receptor (PVR)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 21-343
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Poliovirus Receptor protein is labelled with mFc-His Tag.
- Application
- ELISA
- Purpose
- Recombinant human CD155 protein with C-terminal mouse Fc and 6xHis tag
- Specificity
- CD155 (Trp21-Asn343) mFc (Pro99-Lys330) 6xHis tag
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product PVR Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- Poliovirus Receptor (PVR)
- Alternative Name
- CD155 (PVR Products)
- Background
- The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
- predicted molecular mass of 62.2 kDa after removal of the signal peptide. The apparent molecular mass of CD155-mFc-His is 95-130 kDa due to glycosylation.
- Gene ID
- 5817
- UniProt
- P15151
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome
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