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SARS-CoV-2 Spike (B.1.351 - beta) protein (rho-1D4 tag) Protein

Origin: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Beta Host: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE ELISA, LBA
Catalog No. ABIN6963740
$1,138.66
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  • Key Features
    • Recombinant trimeric S protein of the SARS-CoV-2 variant of concern B.1.351.
    • Contains del 144, K417N, E484K, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H mutations characteristic for the SARS-CoV-2 beta variant (B.1.351).
    Target
    SARS-CoV-2 Spike
    Protein Type
    Recombinant
    Protein Characteristics
    B.1.351 - beta
    Origin
    • 117
    • 8
    • 8
    • 8
    • 7
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Beta
    Source
    • 106
    • 6
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This SARS-CoV-2 Spike protein is labelled with rho-1D4 tag.
    Application
    ELISA, Ligand Binding Assay (LBA)
    Purpose
    This is the spike protein of the mutant strain B.1.351, also commonly known as the "South Africa mutant".
    Specificity
    Mutation that differ from canonical sequence of SPIKE protein: del 144, K417N, E484K, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H
    Characteristics
    "SARS CoV-2 full-length Spike B.1.351 Mutation"
    All viruses undergo fast mutations and adept quickly to the countermeasures that the immune systems creates against them. SARS-CoV-2 of the COVID-19 pandemic is no exception here. During the pandemic multiple mutant strains arose. To help the science combat these mutants we offer the SPIKE protein of these mutants in full-length and active in its native trimeric form, stabilized with the LMNG detergent.
    Purification
    affinity chromatography
    Purity
    > 98 % as determined by SDS-PAGE
  • Application Notes
    ELISA assays, Ligand binding assays (e.g. SPR), Biochemical and biophysical analyses
    Comment

    Further modifications:
    - furin cleavage site "682-RRAR|SV-687" mutated to "682-GSAG|PP-687"
    - C-terminal Rho1D4 tag fused with spacer "GSSG" to protein sequence
    Size: 1286 amino acids (including Rho1D4 tag and linker)

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    20 mM Hepes pH 7.5, 150 mM NaCl, 0.001 % LMNG
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Avoid freeze-thaw cycles
  • Target
    SARS-CoV-2 Spike
    Synonyms
    E2, Surface Glycoprotein, S
    Target Type
    Viral Protein
    Molecular Weight
    142114 Da
    UniProt
    P0DTC2
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