Melanoma gp100 Protein (Fc Tag)

Catalog No. ABIN6964099

Product Details

Target: Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Melanoma gp100 protein is labelled with Fc Tag.

Purpose: Recombinant human PMEL Protein with C-terminal Human Fc tag

Specificity: PMEL (Lys25-Ala595) hFc (Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: affinity purification

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Preservative: Without preservative

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))

Alternative Name: PMEL (PMEL Products)

Synonyms: D12S53E Protein, ME20 Protein, ME20-M Protein, ME20M Protein, P1 Protein, P100 Protein, PMEL17 Protein, SI Protein, SIL Protein, SILV Protein, gp100 Protein, D10H12S53E Protein, D12S53Eh Protein, Pmel17 Protein, Si Protein, Silv Protein, gp87 Protein, RPE1 Protein, MMP115 Protein, silverb Protein, silver Protein, cb397 Protein, fdv Protein, pmel17 Protein, sb:cb397 Protein, silva Protein, wu:fc11g11 Protein, wu:fj24g11 Protein, zgc:136622 Protein, premelanosome protein Protein, premelanosome protein b Protein, premelanosome protein a Protein, PMEL Protein, Pmel Protein, pmelb Protein, pmela Protein

Background: Synonymes: D12S53E, gp100, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV
Description: This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]

Molecular Weight: predicted molecular mass of 46.2 kDa after removal of the signal peptide.The apparent molecular mass of PMEL-hFc is 130-250 kDa due to glycosylation.

Gene ID: 6490

UniProt: P40967