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BAI1 Protein (Fc Tag)

BAI1 Origin: Human Host: HEK-293 Cells Recombinant
Catalog No. ABIN6964229
  • Target See all BAI1 Proteins
    BAI1 (Brain-Specific Angiogenesis Inhibitor 1 (BAI1))
    Protein Type
    Recombinant
    Origin
    • 4
    • 3
    Human
    Source
    • 6
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This BAI1 protein is labelled with Fc Tag.
    Sequence
    BAI1(Ala31-Ser948)+6xHis tag
    Characteristics
    Tagged Protein: C-Human Fc tag
    Purification
    affinity purification
    Top Product
    Discover our top product BAI1 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute with deionized water
    Buffer
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Preservative
    Without preservative
    Storage
    -80 °C
    Storage Comment
    Store at -80°C for 12 months (Avoid repeated freezing and thawing)
    Expiry Date
    12 months
  • Target
    BAI1 (Brain-Specific Angiogenesis Inhibitor 1 (BAI1))
    Alternative Name
    BAI1 (BAI1 Products)
    Synonyms
    BAI1 Protein, GDAIF Protein, B830018M07Rik Protein, R75078 Protein, mKIAA4089 Protein, brain-specific angiogenesis inhibitor 1 Protein, adhesion G protein-coupled receptor B1 Protein, BAI1 Protein, ADGRB1 Protein, LOC100228084 Protein, Adgrb1 Protein
    Background
    Synonymes: BAI1, GDAIF
    Description: Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
    Molecular Weight
    101.64 kDa
    UniProt
    O14514
    Pathways
    p53 Signaling
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