BAI1 Protein (Fc Tag)
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- Target See all BAI1 Proteins
- BAI1 (Brain-Specific Angiogenesis Inhibitor 1 (BAI1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This BAI1 protein is labelled with Fc Tag.
- Sequence
- BAI1(Ala31-Ser948)+6xHis tag
- Characteristics
- Tagged Protein: C-Human Fc tag
- Purification
- affinity purification
- Top Product
- Discover our top product BAI1 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with deionized water
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Preservative
- Without preservative
- Storage
- -80 °C
- Storage Comment
- Store at -80°C for 12 months (Avoid repeated freezing and thawing)
- Expiry Date
- 12 months
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- Target
- BAI1 (Brain-Specific Angiogenesis Inhibitor 1 (BAI1))
- Alternative Name
- BAI1 (BAI1 Products)
- Synonyms
- BAI1 Protein, GDAIF Protein, B830018M07Rik Protein, R75078 Protein, mKIAA4089 Protein, brain-specific angiogenesis inhibitor 1 Protein, adhesion G protein-coupled receptor B1 Protein, BAI1 Protein, ADGRB1 Protein, LOC100228084 Protein, Adgrb1 Protein
- Background
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Synonymes: BAI1, GDAIF
Description: Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008] - Molecular Weight
- 101.64 kDa
- UniProt
- O14514
- Pathways
- p53 Signaling
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